Week 1 · Sun, Oct 11 · 8:25 PM ET

San Francisco 49ers vs Seattle Seahawks: prediction & pick

San Francisco 49ers visit Seattle Seahawks with the model leaning toward San Francisco 49ers. Our projection has SF favored by roughly 2.0 points, a win probability near 56%, and a projected final of SF 23 – SEA 21.

Against the spread

Comparing our projected margin to the posted line of -3.5 for the home team surfaces a gap the model wants to bet. The recommendation is SF +3.5, an edge of about 5.5 points in our favor.

Total (over/under)

Totals-wise, the simulation expects roughly 44.5 points while the book has hung 48.5. That points to the Under 48.5, with about 4.0 points of under edge.

The projection

Running the matchup through the model produces a projected final score of SF 23 – SEA 21, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.

Betting involves risk. Lines move — always confirm the current number at your sportsbook before betting. 21+ where legal.

Bottom line: the model rates this a Strong play at 83% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.