San Francisco 49ers vs Arizona Cardinals: prediction & pick

The model has run the numbers on San Francisco 49ers at Arizona Cardinals and it likes San Francisco 49ers. Our projection has SF favored by roughly 3.0 points, a win probability near 60%, and a projected final of SF 24 – ARI 21.

Against the spread

Comparing our projected margin to the posted line of 8.5 for the home team surfaces a gap the model wants to bet. The recommendation is ARI +8.5, an edge of about 5.5 points in our favor.

Total (over/under)

On the total, the model projects around 45.0 combined points versus a market number of 44.5. That's too tight to bet with confidence — the total is best left alone here.

The projection

Running the matchup through the model produces a projected final score of SF 24 – ARI 21, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.

Bottom line: the model rates this a Strong play at 83% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.