NFLComputerPicksDetroit Lions vs Buffalo Bills: prediction & pick
The model has run the numbers on Detroit Lions at Buffalo Bills and it likes Buffalo Bills. Our projection has BUF favored by roughly 3.0 points, a win probability near 60%, and a projected final of DET 23 – BUF 26.
Against the spread
Where the book sits at -3 on BUF, our simulation disagrees by enough to make this a live spread play. The recommendation is BUF -3, an edge of about 0.0 points in our favor.
Total (over/under)
On the total, the model projects around 49.5 combined points versus a market number of 52.5. That points to the Under 52.5, with about 3.0 points of under edge.
The projection
Running the matchup through the model produces a projected final score of DET 23 – BUF 26, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.
Bottom line: the model rates this a Strong play at 68% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.